Mild Gestational Diabetes Ups Risk for Women and Their Children

Mild Gestational Diabetes Ups Risk for Women and Their Children

Women with gestational diabetes — which was diagnosed using broader “new” criteria — were five times more likely to develop type 2 diabetes and three times more likely to develop prediabetes in the decade after pregnancy than other pregnant women in a large global observational study.

Children whose mothers had had gestational diabetes were also more likely to be obese, have high body fat, a large waist circumference, and skinfolds at age 11 years. (However, for the combined coprimary outcome of overweight or obese, there was no significant difference between 11 year olds of mothers with versus without gestational diabetes).

These findings are from a follow-up of close to 5000 mothers and offspring from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study by William L. Lowe Jr, MD, from Northwestern University, Chicago, Illinois, and colleagues, which was published online September 11 in JAMA.

The researchers diagnosed gestational diabetes using the “new” International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria (Diabetes Care. 2010;33:676-682) published in 2010 and adopted by the World Health Organization and American Diabetes Association, but not the American College of Obstetricians and Gynecologists, which still advises using the stricter Carpenter-Coustan criteria.

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