Scientists from the University of Exeter (UK) have identified a group of genes that play a key role in the aging process.
In particular, they regulate the cleavage factors – molecules that determine the way in which information RNA ripens, reports MedicalXpress.
Splicing refers to the process of excision of nucleotide sequences (introns) from the RNA molecule and cross-linking of the remaining (exons), resulting in the maturation of the molecule.
Thus, introns do not carry information about the amino acid sequence of the polypeptide (protein). Sometimes there is an alternative split, when exons are removed or introns remain, allowing the same gene to code for different polypeptides. An important role here is played by spliceosomes – complexes of RNA and proteins.
Cleavage factors that determine the activity of a spliceosome are in turn regulated by transcription factors – other proteins that bind to DNA and are able to activate or "turn off" the corresponding genes.
Researchers have shown that blocking the ERK and AKT signaling pathways helps to reduce aging cells and rejuvenate cell cultures.
A similar effect can be achieved by inhibiting the major components of these pathways – the FOX01 and ETV6 genes that code for transcription factors. In this case, scientists also noticed an increase in the number of connection factors.
According to scientists, the results of the research will help to develop methods for combating old age and related diseases, such as chronic inflammation or cancer.
As reported by OBOZREVATEL, scientists called explicit signs that genius can determine.