Health

Smoking: Inserm manages to suppress nicotine addiction thanks to the light

Smoking: Inserm manages to suppress nicotine addiction thanks to the light

Another step against smoking. A new study by Inserm has shown that it is possible to manipulate nicotine addiction in mice quickly and reversibly.

"This innovative technology provides a better understanding of the role of different nicotine receptors and neuronal pathways in setting up, maintaining nicotine addiction, as well as in the processes of withdrawal and relapse, important for the identification of new therapeutic targets for nicotine addiction," says Alexandre Mourot. , Research Manager.

Violet light helps stop the attraction for nicotine

Nicotine, the main addictive agent of tobacco, works on the brain by binding to nicotine receptors. Based on this assumption, scientists have modified the nicotine receptor in mice to react a chemical nano switch to light. Under the influence of the violet light, the switch folds the nicotine to remedy: the receiver is "off". Under the influence of the green light, or in the dark, the switch is unfolded and the nicotine works: the receiver is "on".

In concrete terms, violet light helps stop the attraction for nicotine. The team compared the time that mice spent in two compartments, with or without nicotine. Under green light, when nicotine could exert its effect, they noticed that animals preferred the compartment with nicotine. However, under violet light, the mice spent so much time in each compartment, which proved that they were no longer attracted by nicotine.

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